diff --git a/python/cudf/cudf/pandas/__main__.py b/python/cudf/cudf/pandas/__main__.py
index 8d9c0e280840..7410f26229b4 100644
--- a/python/cudf/cudf/pandas/__main__.py
+++ b/python/cudf/cudf/pandas/__main__.py
@@ -52,7 +52,9 @@ def profile(function_profile, line_profile, fn):
         raise RuntimeError("Enabling the profiler requires a script name.")
     if line_profile:
         with open(fn) as f:
-            lines = f.readlines()
+            # lines_with_profiling joins the lines with "\n", so they must not
+            # keep their own line endings (the cell magic splits on "\n" too).
+            lines = f.read().split("\n")
 
         with tempfile.NamedTemporaryFile(mode="w+b", suffix=".py") as f:
             f.write(lines_with_profiling(lines, function_profile).encode())
diff --git a/python/cudf/cudf_pandas_tests/test_main.py b/python/cudf/cudf_pandas_tests/test_main.py
index 8448c0756e46..a0eb754e4e35 100644
--- a/python/cudf/cudf_pandas_tests/test_main.py
+++ b/python/cudf/cudf_pandas_tests/test_main.py
@@ -1,6 +1,7 @@
 # SPDX-FileCopyrightText: Copyright (c) 2024-2026, NVIDIA CORPORATION & AFFILIATES. All rights reserved.
 # SPDX-License-Identifier: Apache-2.0
 
+import re
 import subprocess
 import tempfile
 import textwrap
@@ -59,6 +60,16 @@ def test_run_cudf_pandas_line_profile_preserves_file(tmp_path):
     assert str(script) in res
 
 
+def test_run_cudf_pandas_line_profile_reports_script_line_numbers(tmp_path):
+    # ``--line-profile`` must report the line numbers of the original script.
+    script = tmp_path / "script.py"
+    script.write_text("x = 1\ny = 2\nz = 3\nprint(x + y + z)\n")
+
+    res = _run_python(cudf_pandas=True, command=f"--line-profile {script}")
+    reported = re.findall(r"^[│|]\s*(\d+)\s*[│|]", res, re.MULTILINE)
+    assert reported == ["1", "2", "3", "4"]
+
+
 def test_run_cudf_pandas_with_script_with_cmd_args():
     input_args_and_code = """-c 'import pandas as pd; df = pd.DataFrame({"a": [1, 2, 3]}); print(df["a"].sum())'"""