diff --git a/src/bentoml/_internal/io_descriptors/pandas.py b/src/bentoml/_internal/io_descriptors/pandas.py
index 7e6b899e45e..66e7c32b900 100644
--- a/src/bentoml/_internal/io_descriptors/pandas.py
+++ b/src/bentoml/_internal/io_descriptors/pandas.py
@@ -414,7 +414,6 @@ def predict(inputs: pd.DataFrame) -> pd.DataFrame: ...
                                 "xlsx": "read_excel",
                                 "hdf5": "read_hdf",
                                 "parquet": "read_parquet",
-                                "pickle": "read_pickle",
                                 "sql": "read_sql",
                             }[ext],
                         )(sample)