diff --git a/nightly_test_constraints.txt b/nightly_test_constraints.txt
index 082ef586a9..172bacf012 100644
--- a/nightly_test_constraints.txt
+++ b/nightly_test_constraints.txt
@@ -72,7 +72,7 @@ cramjam==2.8.4
 crcmod==1.7
 cron-descriptor==1.4.5
 croniter==3.0.3
-cryptography==43.0.1
+cryptography==50.0.0
 Cython==3.0.11
 debugpy==1.8.7
 decorator==5.1.1
diff --git a/test_constraints.txt b/test_constraints.txt
index 4102b1f0a3..18bfeaa816 100644
--- a/test_constraints.txt
+++ b/test_constraints.txt
@@ -72,7 +72,7 @@ cramjam==2.8.4
 crcmod==1.7
 cron-descriptor==1.4.5
 croniter==3.0.3
-cryptography==43.0.1
+cryptography==50.0.0
 Cython==3.0.11
 debugpy==1.8.7
 decorator==5.1.1