KINC outputs a "tidy" network that has edges containing two genes. Gene 1 is a "Source" edge and gene 2 is a "Target" edge.
The labels "Source" and "Target" imply causality, but KINC is not capable of predicting causality.
From: Mercatelli, D., Scalambra, L., Triboli, L., Ray, F., & Giorgi, F. M. (2020). Gene regulatory network inference resources: A practical overview. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1863(6), 194430. https://doi.org/10.1016/j.bbagrm.2019.194430
"GRN reconstruction methods based on coexpression (see later) provide a network of relationships with no information on the directionality of the identified interactions. In other words, the correlation between two gene expression levels does not imply a specific causal relationship between the two, nor a direct one."
KINC outputs a "tidy" network that has edges containing two genes. Gene 1 is a "Source" edge and gene 2 is a "Target" edge.
The labels "Source" and "Target" imply causality, but KINC is not capable of predicting causality.
From: Mercatelli, D., Scalambra, L., Triboli, L., Ray, F., & Giorgi, F. M. (2020). Gene regulatory network inference resources: A practical overview. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1863(6), 194430. https://doi.org/10.1016/j.bbagrm.2019.194430
"GRN reconstruction methods based on coexpression (see later) provide a network of relationships with no information on the directionality of the identified interactions. In other words, the correlation between two gene expression levels does not imply a specific causal relationship between the two, nor a direct one."