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1 change: 1 addition & 0 deletions public/pancan_metaprism_2023/LICENSE
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The data are available under the ODC Open Database License (ODbL)(http://opendatacommons.org/licenses/odbl/1.0/) (summary available here: http://www.opendatacommons.org/licenses/odbl/1-0/summary/): you are free to share and modify the data so long as you attribute any public use of the database, or works produced from the database; keep the resulting data-sets open; and offer your shared or adapted version of the data-set under the same ODbL license.
72 changes: 72 additions & 0 deletions public/pancan_metaprism_2023/README.md
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# META-PRISM

**Publication** : The study is now published in Cancer Discovery and is freely available at https://pubmed.ncbi.nlm.nih.gov/36862804/.
**Local Instance** : <https://cbioportal.gustaveroussy.fr:8081/study/summary?id=metaprism_2023>.
**Local Instance** : <https://nextcloud.gustaveroussy.fr/s/dbCwPWKZMj6BmDp>.
**Study Id** : pancan_metaprism_2023
**Reference genome** : GRCh37

## Description

## Clinical data: (data_clinical_patient.txt) (data_clinical_sample.txt)

- `Supplementary_Table_1.xlsx` Clinical characteristics and samples of the 1,031 patients included in the META-PRISM
cohort.

**Clinical data remapping**:

| Original column | Renamed column | Patient/Sample Attribute |
| ---| ---| --- |
| Subject_Id | Patient_Id | Patient |
| Sex | Sex | Patient |
| Age_At_Biopsy | AGE_AT_BIOPSY | Patient |
| Oncotree_Code | Oncotree_Code | Sample |
| Primary_Tumor_Site | Primary Site | Sample |
| Histology | Histology | Sample |
| Metastatic_Sites | Metastatic Site | Sample |
| Treatments_Before_Biopsy | Treatments Before Biopsy | Patient |
| Albumin_At_Biopsy(g/L) | Albumin At Biopsy(g/L) | Patient |
| Lactate_Dehydrogenase_At_Biopsy(UI/L) | Lactate Dehydrogenase At Biopsy(UI/L) | Patient |
| Neutrophils_At_Biopsy(10^9/L) | Neutrophils At Biopsy(10^9/L) | Patient |
| Lymphocytes_At_Biopsy(10^9/L) | Lymphocytes At Biopsy(10^9/L) | Patient |
| GRIM_Score | Gustave Roussy Immune Score | Patient |
| Alcohol | Alcohol History | Patient |
| Smoking_History | Smoking History | Patient |
| Vital_Status | OS status. | Patient |
| Sample_Id_DNA_T | Sample_Id | Sample |

## Segmented data: (data_cna_hg19.seg)

- `Data_Table_5.somatic_cna_segments.tsv` Table of all 42,769 curated copy-number segments identified in 569
WES tumor/normal sample pairs.

## Mutation data: (data_mutations.txt)

- `Data_Table_3.somatic_mutations.maf.gz` Table of all 117,747 somatic mutations detected in 569 analyzed
WES tumor/normal sample pairs. Only mutations that pass all filters are included.

## Zscore Expression data: (data_mrna_seq_tpm_zscores_ref_all_samples.txt)

- `Data_Table_2.rna_gene_tpm.tsv.gz` Table in 58,288 x 948 format with the expression TPM of 58,288 genes in
the 947 RNAseq tumor samples.

## SV data: (data_sv.txt)

- `Data_Table_10.rna_fusions.tsv.gz` Table of all 707,027 fusion calls as identified by Arriba v1.2.0, EricScript v0.5.5,
Pizzly v0.37.3, or StarFusion v1.8.1.

## Copy number data: (data_cna.txt)

- `Data_Table_1.rna_gene_counts.tsv.gz` Table in 58,288 x 948 format with the expression raw counts of 58,288 genes in
the 947 RNAseq tumor samples.

## Mutational Signatures:

(data_mutational_signatures_counts_SBS.txt)
- `Data_Table_9.sbs_96_signature_counts.tsv` Table in 78 x 451 format with the mutation counts contributed by each of
the 78 signatures from COSMIC SBS v3.2 database in the 450 WES tumor samples .

(data_mutational_signatures_contribution_SBS.txt)
- `Data_Table_11.rna_ssgsea_immune.tsv` Table in 29 x 948 format with the functional gene expression signatures (ssGSEA
scores) on the 29 gene sets in 947 RNAseq tumor samples.

6 changes: 6 additions & 0 deletions public/pancan_metaprism_2023/case_lists/cases_all.txt

Large diffs are not rendered by default.

6 changes: 6 additions & 0 deletions public/pancan_metaprism_2023/case_lists/cases_cna.txt
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cancer_study_identifier: pancan_metaprism_2023
stable_id: pancan_metaprism_2023_cna
case_list_name: Samples with CNA data
case_list_description: Samples with CNA data (569 samples)
case_list_category: all_cases_with_cna_data
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